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Green Tea Protects Mice Against Powerful Carcinogens

Study description: Mice were exposed to powerful carcinogens known to cause cancers of the stomach and lung. Some of the mice received green tea extract in water at various points during the experiment.
 

Type of study:  Animal
 

Study methods: At the beginning of the experiment, one group of mice received green tea extract in water while the other group did not. Then, all of the mice were exposed to the cancer-causing substances diethylnitrosamine (DEN) and benzo(a)pyrene (BP), in order to induce tumors in the forestomach and lungs. Some mice continued to receive green tea water during the post-initiation period and throughout the length of the experiment.

What happened:
In the mice who received green tea water throughout the experiment, there was a decrease in the number of mice who developed tumors and the number of tumors that developed. The mice developed up to 82% fewer DEN-induced stomach cancers and up to 66% fewer BP-induced tumors, thanks to green tea.
 

Researchers' conclusion: “…green tea possesses chemopreventive effects against carcinogen-induced tumorigenesis in internal body organs…”
 

Citation: Katiyar SK, Agarwal R, Zaim MT, Mukhtar H. Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea. Carcinogenesis 1993;14(5):849-55. (Click here to read PubMed study abstract.)

 


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