Painting Green Tea
Polyphenols on the Skin Protects Against Skin Cancer
Study description:
Researchers tested the protective effects of
green tea polyphenols (GTP) on stage I and stage II skin tumor promotion in
hairless mice. For one part of the study, researchers applied green tea
polyphenols to the mice each time they applied a tumor promoter. For another
part of the study, the polyphenols were applied
continuously as the mice went through a tumor-promoting protocol. For the
control group, other mice
were exposed to tumor promoters but did not have green tea polyphenols
applied to their skin.
Type of study: Animal
What happened:
The mice who had the polyphenols applied to their skins with each application of
the cancer promoter had 42-50% less tumor multiplicity and 43-54% less tumor
growth than those that did not receive polyphenols. But those who had green tea
polyphenols applied continuously had 71% less tumor multiplicity, 37%
fewer new tumors and 74% less tumor growth.
Researchers' conclusion:
The researchers noted that applying green tea
polyphenols “inhibits both stage I and stage II of skin tumor promotion and …
the inhibition of tumor promotion depends on the duration of GTP treatment.”
Citation:
Katiyar SK, Agarwal R,
Mukhtar H. Inhibition of both stage I and stage II skin tumor promotion in
SENCAR mice by a polyphenolic fraction isolated from green tea: inhibition
depends on the duration of polyphenol treatment. Carcinogenesis
1993;14(12): 2641-43. (Click here to read PubMed study
abstract.)
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Nadine Taylor, M.S., R.D. presents
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