Green Tea Fights the Deadly Skin Cancer, Melanoma

Background: Melanoma is a potentially deadly form of skin cancer that begins in the skin's pigment cells. In advanced cases, it spreads to the internal organs and is extremely hard to treat.

Study description: Researchers looked at the effects of EGCg on two melanoma cell lines, as well as on normal pigment-producing skin cells.

Type of study: "Test-tube"

What happened: The growth and viability of both melanoma cells lines decreased as concentrations of EGCg increased. Cell multiplication decreased, "cell suicide" increased, and colony formation was inhibited.

Interestingly, the normal pigment-producing cells were not affected, even when exposed to the same concentrations of EGCg.

Researchers' conclusion:  "Thus, EGCg, alone or in conjunction with current therapies, could be useful for the management of melanoma."

Citation:  Nihal M, Ahmad N, Mukhtar H, Wood GS. Anti-proliferative and proapoptotic effects of (-)-epigallocatchin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. International Journal of Cancer 2005;114(4):513-21.


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