Green Tea Catechins Fight Constriction of Arteries

Background: High blood pressure can result from many things, among them arteries that are too constricted. This constriction can occur because the smooth muscle cells lining the artery walls tighten up. Or it may be because these same cells increase in size and number, leading to thicker vessel walls and narrower vessels.

Whatever the cause of the constriction, getting the blood vessels to relax and widen is an important step in treating high blood pressure.

Type of study: "Test-tube"

Study methods: In the lab, green tea's EC and EGCg were mixed with rat arterial smooth muscle cells to see if the catechins could induce blood vessel-relaxing and anti-overgrowth responses. Before adding the catechins, the cells were exposed to a substance that constricted them.

What happened: The catechins relaxed the rat arterial cells and inhibited their overgrowth.

Citation: Chen ZY, Law WI, Yao XQ, et al. Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells. Acta Pharmacol Sin 2000;21(9):835-40. (Click here to read PubMed study abstract.)


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